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ecathead 
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Calculate average TAC with this tool. ecathead help you calculate the average TAC from all pixels in a PET image or scan file in ECAT 6.3 or 7 format, and write it to a specified count-rate file with mid frame times in seconds, by default.
Frame start and end times are saved, if count-rate file is named as *.dft, otherwise only frame mid times; option -format overrides this. Decay correction is not changed: if image or sinogram is decay corrected, head curve will be decay corrected, and vice versa.
Usage: ecathead [Options] <Dynamic image/sinogram> <Head curve>
Options:
-thr[=<Threshold-%>,<<Nr of frames>|<a>|<fh>>]
Count-rate curve is calculated from pixels exceeding the specified threshold level, or 10% level with only -thr. Specified number or default five last frames are used in determining threshold level; alternatively, with 'a' all frames, or with 'fh' the first half of frames are used in thresholding.
Without -thr option all pixels are included.
-m[in]
Count-rate curve times are written in minutes (sec by default)
-s[ec]
Count-rate curve times are written in seconds (this is the default)
-format=<cr|dft>
File is written in 'count-rate' format with no titles and with frame mid times only, or, with title lines with PET frame start and end times (dft)
-keepnegat
Frames with negative mean value are not set to zero.
-sum
By default, mean of all or thresholded pixels is calculated; with this option, the sum of pixel values is reported.
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.
The license of this software is Freeware, you can free download and free use this calculator software.